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在水相中,采用化学共沉淀法以FeCl_3·6H_2O和FeSO_4·7H_2O为原料合成超顺磁性Fe_3O_4纳米粒子,将磁性纳米粒子加入到正硅酸乙酯(TEOS)的醇水体系中,使磁性纳米粒子表面生成一层无定型SiO_2包覆层,再以3-(甲基丙烯酰氧)丙基三甲氧基硅烷(MPTS)对其进行修饰,使磁性纳米粒子表面接入丰富的功能双键,与巯基乙酸、乙二胺修饰后的CdSe/CdS量子点连接,得到磁性荧光双功能纳米微球,并对其进行结构表征和性能测试。结果表明,合成的磁性纳米粒子粒径约为40nm,荧光强度约为450a.u.,饱和磁化强度为32.2emu/g。这种合成简便的磁性荧光双功能纳米材料有望在靶向治疗、免疫检测、细胞的分离和催化等领域得到广泛应用。
In the aqueous phase, superparamagnetic Fe_3O_4 nanoparticles were synthesized by chemical coprecipitation using FeCl 3 · 6H 2 O and FeSO 4 · 7H 2 O as raw materials. The magnetic nanoparticles were added to TEOS alcohol and water system to make the magnetic An amorphous SiO 2 coating is formed on the surface of the nanoparticles, which is then modified with 3- (methacryloyloxy) propyltrimethoxysilane (MPTS) to attach the surface of the magnetic nanoparticles to rich functional double bonds , Which was connected with CdSe / CdS quantum dots modified with thioglycolic acid and ethylenediamine to obtain magnetic fluorescent bifunctional nanospheres, and its structure and properties were tested. The results show that the synthesized magnetic nanoparticles have a diameter of about 40nm, a fluorescence intensity of about 450a.u. and a saturation magnetization of 32.2emu / g. This simple synthesis of magnetic fluorescent bifunctional nanomaterials is expected to be widely used in the field of targeted therapy, immunoassay, cell separation and catalysis.