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目的探讨感染性休克患者血清淀粉酶水平与疾病严重程度及预后的关系。方法45例感染性休克患者,根据28d生存情况分为生存组(23例)和死亡组(22例),检测第1天和第2天的血清淀粉酶水平,采用急性生理学及慢性健康状况评分(APACHEⅡ评分)和全身感染相关性器官功能衰竭评分(SOFA评分)评估疾病严重程度和预后,并分析血清淀粉酶水平与APACHEⅡ评分、SOFA评分的相关性。结果第1天和第2天,生存组血清淀粉酶水平分别为(122.4±100.2)U/L和(137.8±110.1)U/L,均低于死亡组的(221.3±169.7)U/L和(288.2±197.3)U/L(P<0.05)。第1天,生存组APACHEⅡ评分和SOFA评分均低于死亡组(P<0.05)。所有患者第1天的血清淀粉酶水平与APACHEⅡ评分和SOFA评分呈正相关(r=0.954和0.836,P<0.05)。结论感染性休克患者常见淀粉酶水平升高,与疾病严重程度相关,并能提示患者的预后。
Objective To investigate the relationship between serum amylase level and the severity and prognosis of septic shock patients. Methods Seventy-five septic shock patients were divided into survival group (n = 23) and death group (n = 22) according to their 28-day survival. The levels of serum amylase on day 1 and 2 were measured. Acute physiology and chronic health status score (APACHEⅡscore) and organ failure-related organ failure score (SOFA score) to evaluate the severity and prognosis of the disease, and to analyze the correlation between serum amylase level and APACHEⅡscore and SOFA score. Results On the first day and the second day, the levels of serum amylase in the survival group were (122.4 ± 100.2) U / L and (137.8 ± 110.1) U / L, respectively, which were lower than those in the death group (221.3 ± 169.7) U / L and (288.2 ± 197.3) U / L (P <0.05). On the first day, APACHEⅡscore and SOFA scores in survival group were lower than those in death group (P <0.05). Serum amylase levels on day 1 were positively correlated with APACHE II scores and SOFA scores (r = 0.954 and 0.836, P <0.05). Conclusion The common amylase level in patients with septic shock is related to the severity of the disease and can indicate the prognosis of the patients.