Acanthopanax senticosus aqueous extract,at 10,5 and 2.5 μg/mL,lessened hypoxia-induced PC12 cell injury.Pretreatment with the extract upregulated Bcl-2 expression,downregulated Bax expression,elevated superoxide dismutase activity,diminished malondialdehyde content,relieved Ca2+ overloading,and suppressed apoptosis of PC12 cells.These effects were most pronounced at 10 μg/mL.These results suggest that Acanthopanax senticosus aqueous extract protects PC12 cells from hypoxia-induced injury in a dose-dependent manner. Acanthopanax senticosus aqueous extract, at 10,5 and 2.5 μg / mL, lessened hypoxia-induced PC12 cell injury. Treatment with the extract upregulated Bcl-2 expression, downregulated Bax expression, elevated superoxide dismutase activity, diminished malondialdehyde content, relieved Ca 2+ overloading, and suppressed apoptosis of PC 12 cells. These results were most pronounced at 10 μg / mL. These results suggest that Acanthopanax senticosus aqueous extract protects PC12 cells from hypoxia-induced injury in a dose-dependent manner.