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目的:评价原发性高血压(EH)患者动态血压节律异常对利钠肽及左室质量的影响。方法:根据24h动态血压结果将65例EH患者分为杓形高血压组与非杓形高血压组,分别进行了血心房利钠肽(ANP)、脑钠肽(BNP)及超声心动图测定。结果:杓形高血压组与非杓形高血压组的ANP、BNP及左室质量指数(LVMI)均显著高于对照组(P<0.01);其中非杓形高血压组显著高于杓形高血压组(P<0.01);且ANP、BNP浓度与LV-MI呈正相关(R=0.45,0.67;P<0.01)。结论:EH患者血压昼夜节律异常者,心脏ANP分泌增加,与LVMI呈正相关性。
Objective: To evaluate the effect of abnormal rhythm of blood pressure on the natriuretic peptide and left ventricular mass in patients with essential hypertension (EH). Methods: According to 24h ambulatory blood pressure results, 65 patients with EH were divided into two groups: the group with the dipper hypertension and the non-dipper hypertension group. The levels of ANP, BNP and echocardiography . Results: The ANP, BNP and LVMI were significantly higher in the non-dipper group and the non-dipper group than in the control group (P <0.01). The non-dipper hypertensive group was significantly higher than the dipper Hypertension group (P <0.01). The ANP and BNP levels were positively correlated with LV-MI (R = 0.45,0.67; P <0.01). Conclusion: The abnormal circadian rhythm of blood pressure in patients with EH increased cardiac ANP secretion, which was positively correlated with LVMI.