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目的通过检测肺炎支原体肺炎(MPP)患儿红细胞膜表面CD35、CD58的数量变化,探讨其在MPP发病中的作用。方法对2001-09—2002-08唐山市人民医院收治的37例MPP患儿,按病情程度分为2组轻症组(无并发症组);重症组(有并发症组)。对照组为正常儿童。采用酶联法测定MPP患儿及正常对照儿童红细胞膜CD35、CD58数量变化并进行对比。结果MPP患儿CD35低于正常对照儿童,尤其是伴有其他系统并发症的重症组下降明显,差异有显著性;MPP患儿CD58水平低于正常对照组,尤以伴有肺外并发症的重症组为显著。结论红细胞膜CD35、CD58变化在MPP发病机制中起重要作用,对判断病情及预后、观察疗效、指导治疗,尤其是对伴有肺外并发症的重症患儿有临床实用价值。
Objective To detect the changes of the number of CD35 and CD58 on the surface of erythrocyte membrane in children with Mycoplasma pneumoniae pneumonia (MPP) and to explore its role in the pathogenesis of MPP. Methods Thirty-seven MPP children admitted to Tangshan People’s Hospital from September 2001 to August 2008 were divided into two groups: mild group (no complication group) and severe group (with complication group). The control group was normal children. Enzyme-linked immunosorbent assay was used to detect the changes of erythrocyte membrane CD35 and CD58 in children with MPP and normal controls. Results The level of CD35 in children with MPP was significantly lower than that in children with normal control, especially in the severe group with other systemic complications. The level of CD58 in children with MPP was lower than that in the control group, especially in patients with MPP Severe group was significant. Conclusion The changes of erythrocyte membrane CD35 and CD58 plays an important role in the pathogenesis of MPP. It is of clinical value in judging the condition and prognosis, observing the curative effect and guiding the treatment, especially for children with severe pulmonary complications.