六十年代以前人们认为氯乙烯属低毒物质,在高浓度下仅引起一过性麻醉,车间空气中的最高容许浓度订为500PPm。国内孙氏曾有综述。1963年后,对氯乙烯毒性的认识有了新的发展。德、日、美、意各国学者均报导在聚合工段的清釜工中发现有肢端溶骨症。1971年Viola报道高浓度氯乙烯可引起大鼠皮肤及肺等肿瘤。1973年Maltoni报道氯乙烯引起实验动物的肝血管肉瘤。自1974年1月美国首次报道肝血管肉瘤病例后,近年来文献中陆续有报告。所以氯乙烯的危害问题,目前已引起广泛的重视,美国已将车间空气中的最高容许浓度修改为1PPm。现将国内外有关文献作一简要的综述。氯乙烯的代谢氯乙烯是一种相对无活性的小分子化合物,可经消化道、呼吸道进入人体。经吸入者约82％以原物由肺中排出。大鼠吸入低浓度的氯乙烯(低于100PPm),主要经醇脱氢酶催 Before the sixties people think that vinyl chloride is a low-toxic substances, only caused a transient anesthesia at high concentrations, the maximum allowable concentration in the workshop set at 500PPm. Sun has been domestic review. After 1963, there was a new development in the understanding of the toxicity of vinyl chloride. Scholars from Germany, Japan, the United States, and Italy all reported that they had osteolytic leptospirosis in the autoclave at the polymerization station. 1971 Viola reported that high concentrations of vinyl chloride can cause rat skin and lung tumors. Maltoni reported in 1973 that vinyl chloride caused hepatic angiosarcoma in experimental animals. Since the first report of the case of hepatic angiosarcoma in January 1974 in the United States, there have been reports in the literature in recent years. Therefore, the harm of vinyl chloride has attracted widespread attention. The United States has revised the maximum allowable concentration of air in the workshop to 1 ppm. Now a brief overview of the literature at home and abroad. Vinyl chloride metabolism Vinyl chloride is a relatively inactive small molecule compounds, through the digestive tract, respiratory tract into the body. Approximately 82% of inhaled persons are excreted from the lungs as original. Rats inhaled low concentrations of vinyl chloride (less than 100PPm), mainly by alcohol dehydrogenase