DNA上的化学标记会影响基因表达。在一项新的研究中,来自美国、日本、西班牙和沙特阿拉伯的研究人员开发出一种新的技术来校正这些化学标记发生的致病性异常。这些化学修饰统称为表观基因组,在发育和疾病中与基因组序列本身一样发挥着越来越重要的作用。相关研究结果发表在Science期刊上,论文标题为“Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells”。 Chemical labeling on DNA can affect gene expression. In a new study, researchers from the United States, Japan, Spain and Saudi Arabia developed a new technique to correct pathogenic abnormalities that occur with these chemical markers. These chemical modifications, collectively referred to as the epigenome, play an increasingly important role in the development and disease as the genome sequence itself. Relevant findings were published in Science journals titled “Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells.”