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目的探讨丙泊酚复合芬太尼、咪唑安定用于妇产科门诊手术中的麻醉效果及安全性。方法以86例妇科门诊手术患者为研究对象，给予丙泊酚、芬太尼联合咪唑安定，并以同期使用丙泊酚联合芬太尼的86例为对照，观察两组麻醉效果。结果观察组药物在睫毛反射消失节点时对呼吸和循环的影响明显小于对照组（P＜0.05）；起效平均时间（2.2±0.8）min，明显短于对照组（P＜0.05）；丙泊酚用量（82.3±25.5）mg，明显少于对照组（P＜0.01）；术中躁动和不良反应情况少于对照组（P＜0.05或0.01）。结论丙泊酚、芬太尼联合咪唑安定应用于妇科门诊手术起效快、对呼吸和循环的影响小、丙泊酚用量低，麻醉效果优于丙泊酚联合芬太尼，值得临床进一步研究推广。“,” Objective To investigate the anesthetic ef ects and safety of propofol combined with fentanyl, midazolam in obstetrics and gynecology outpatient operation. Methods Made 86 cases of gynecological operation patients as the research object, given propofol combined with fentanyl midazolam, and 86 patients used propofol combined with fentanyl during the same period were as the control, the anesthetic effects of two groups were observed. Results The ef ects of drug used for observe group on respiration and circulation were significantly lower than that of control group on the node of eyelash reflex disappeared (P<0.05);onset time was (2.2±0.8)min, which was significantly shorter than the control group (P<0.05); propofol dosage was (82.3±25.5)mg, which was significantly less than the control group (P<0.01);agitation and adverse reactions were less than the control group(P<0.05 or 0.01). Conclusion Propofol combined with fentanyl midazolam used in gynecological outpatient operation had the advantages of onset time fast, less ef ect on respiration and circulation, low dosage of propofol, the anesthesia ef ect was better than that of propofol combined with fentanyl, which was worthy of further clinical study.