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回顾分析68例重症肌无力患者的药物治疗史,针对抗胆碱酯酶药、糖皮质激素不良反应的发生情况,探讨重症肌无力患者所受的药源性损伤及其护理对策。68例患者在服药期间均出现了程度不一的不良反应,其中抗胆碱酯酶药所致的损伤主要表现在消化道,按频数高低依次为腹痛57例(83.8%)、腹泻50例(73.5%)、唾液过多31例(45.5%)。糖皮质激素所致的损伤主要有消化道出血19例(27.9%)、肌无力加重10例(14.7%)、诱发肌无力危象1例(1.4%)。提示临床护士要重视患者的药源性损伤,通过调整给药时间、密切观察不良反应、加强医护合作、积极对症治疗等,把药源性损伤降到最低程度。
A retrospective analysis of 68 cases of myasthenia gravis patients with drug treatment history, for anticholinergic drugs, glucocorticoid adverse reactions occurred in patients with myasthenia gravis drug-induced injury and nursing strategies. 68 patients in the medication during the emergence of varying degrees of adverse reactions, including anti-cholinesterase-induced damage mainly in the digestive tract, according to the frequency of abdominal pain were 57 cases (83.8%), diarrhea in 50 cases ( 73.5%), excessive saliva in 31 cases (45.5%). Glucocorticoid-induced injury mainly included gastrointestinal bleeding in 19 cases (27.9%), aggravated muscle weakness in 10 cases (14.7%), and induced myasthenic crisis in 1 case (1.4%). Prompted clinical nurses should pay attention to the patient’s drug-induced injury, by adjusting the timing of administration, close observation of adverse reactions, strengthening medical cooperation, positive symptomatic treatment, the drug-induced damage to a minimum.