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现将甲磺丁脲(D860,甲糖宁)、氯磺丙脲、优降糖等磺酰脲类口服降血糖药配伍问题作一简单介绍。降血糖药+磺胺类连续服用甲磺丁脲的患者,如用磺胺苯吡唑有时会产生急性低血糖症。一是由于用磺丁脲代谢物氧化为羟甲基物的过程被磺胺苯吡唑所阻抑之故;二是由于磺胺苯吡唑置换了与血浆蛋白结合的甲磺丁脲在血液的游离浓度,而运入组织的药量大大增加,使降血糖的作用增强。磺胺嘧啶、磺胺二甲氧嘧啶与甲磺丁尿不产生这种相互作用;磺胺二甲嘧啶、磺胺异恶唑(菌得清)与氯磺丙脲并用时亦可呈现相加作用,能引起低血糖。
Now metobutamide (D860, Jiaoshu Ning), chlorpropamide, glibenclamide and other sulfonylurea oral hypoglycemic compatibility issues a brief introduction. Hypoglycemic agents + sulfonamides Patients taking metoxicamide continuously, such as sulfaphenazole, sometimes develop acute hypoglycemia. One is due to the sulfometallurgy metabolite oxidized to methylol process was inhibited by sulfaphenazole; II is due to sulfapiram replacement with plasma protein-bound medetudin in the blood of the free Concentration, and greatly increased the amount of drugs into the organization, so that the role of hypoglycemic increased. Sulfadiazine, sulfadimethoxine and metsulfuron-methyl did not produce this interaction; sulfamethazine, sulfisoxazole (bacteria were clear) and chlorpropamide and may also be used in combination, can cause Hypoglycemia.