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代谢综合征主要表现为腹型肥胖、糖耐量异常、高血压、血脂异常以及炎症和血栓状态。血清睾酮水平低下与代谢综合征密切相关,是糖尿病、动脉粥样硬化、心血管疾病的独立危险因素。横断面流行病学研究结果表明,血清睾酮和胰岛素敏感性有直接关系,患者的低睾酮水平增加其患2型糖尿病的风险,血清睾酮和性激素结合球蛋白水平低下能预测代谢综合征发生率较高。睾酮补充治疗能减少体脂含量、减少胰岛素抵抗和改善血糖控制,能抑制糖尿病和动脉粥样硬化的发展。血清低睾酮水平应该作为代谢综合征定义的要素之一。
Metabolic syndrome is mainly manifested as abdominal obesity, impaired glucose tolerance, hypertension, dyslipidemia, and inflammation and thrombus status. Low levels of serum testosterone and metabolic syndrome are closely related to diabetes, atherosclerosis, cardiovascular disease, an independent risk factor. Cross-sectional epidemiological studies have shown that serum testosterone and insulin sensitivity is directly related to the patient’s low testosterone levels increase the risk of type 2 diabetes, serum testosterone and sex hormone binding globulin levels can predict the incidence of metabolic syndrome than high. Testosterone replacement therapy can reduce body fat content, reduce insulin resistance and improve blood sugar control, can inhibit the development of diabetes and atherosclerosis. Serum low testosterone levels should be defined as one of the elements of the metabolic syndrome.