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消炎痛预处理对醋氨酚所致小鼠肝损伤有明显的保护作用。300mg/kg剂量的醋氨酚引起严重的肝损伤,如果在给醋氨酚前24小时皮下一次注射消炎痛(10mg/kg),则损伤明显减轻。经消炎痛预处理动物的SGPT由对照的组1666±43下降到554±153 u/100ml,组织学检查也明显减轻,500mg/kg剂量的醋氨酚引起的死亡率由90％降到45％。小鼠经苯巴比妥钠(80mg/kg)处理三天,以增加细胞色素P_(450)含量,此时醋氨酚引起的肝损伤加重,且由消炎痛诱导的肝保护作用被消除。
Indomethacin pretreatment has obvious protective effect on the liver injury induced by acetaminophen in mice. Acetaminophen at a dose of 300 mg / kg caused severe liver damage, with significant reductions if indomethacin (10 mg / kg) was given subcutaneously 24 hours prior to acetaminophen. The SGPT of animals pretreated with indomethacin decreased from 1666 ± 43 to 554 ± 153 u / 100ml in the control group, and the histological examination was also significantly reduced. The mortality rate of acetaminophen at the dose of 500 mg / kg was reduced from 90% to 45% . Mice were treated with phenobarbital sodium (80 mg / kg) for three days to increase the cytochrome P450 level, at which time acetaminophen-induced liver injury was aggravated and the protective effect of indomethacin-induced liver was abolished.