论文部分内容阅读
目的观察螺内酯联合氯沙坦治疗老年高血压舒张性心力衰竭(DHF)的疗效。方法 78例老年高血压伴有DHF患者,随机分为治疗组和对照组,每组各39例,对照组给予常规治疗基础上加用氯沙坦;治疗组在对照组基础上加用螺内酯,疗程共6个月,比较两组治疗前后6min步行试验、脑钠肽、超声心动图。结果治疗组治疗后6min步行试验和左心室舒张功能超声指标均改善(P<0.05)、脑钠肽(BNP)水平下降,与对照组比较差异有统计学意义(P<0.05)。结论螺内酯联合氯沙坦可改善老年高血压并发DHF患者心脏舒张功能,提高活动耐量。
Objective To observe the efficacy of spironolactone combined with losartan in the treatment of elderly hypertensive patients with diastolic heart failure (DHF). Methods 78 elderly hypertensive patients with DHF were randomly divided into treatment group and control group, 39 cases in each group. The control group was given conventional therapy plus losartan. The treatment group was treated with spironolactone, A total of 6 months course of treatment, compared two groups before and after 6min walking test, brain natriuretic peptide, echocardiography. Results The 6-minute walking test and the left ventricular diastolic function in the treatment group were improved (P <0.05), and the levels of BNP decreased compared with the control group (P <0.05). Conclusion Spironolactone combined with losartan can improve diastolic function and increase activity tolerance of elderly hypertensive patients with DHF.