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本研究用Wistar雄性大鼠背部体表面积约20％的三度烧伤为模型。烧伤后,血浆、肝脏硒的浓度降低,与硒有关的谷胱甘肽过氧化物酶的活性减小,同时血浆VE明显降低,而RBC和肝脏VE的含量并没有降低。伤后每天补充2.3μgSe/100gbw的亚硒酸钠,RBC和肝脏VE的含量明显低于正常对照组,血浆VE也较烧伤不补硒组低,同时使血浆总巯基的含量降低更为明显。结果表明,烧伤后补充硒可使VE的消耗增多。
In this study, Wistar male rats with a body surface area of about 20% of the third-degree burn as a model. After burn, the concentration of selenium in plasma and liver decreased, the activity of selenium-related glutathione peroxidase decreased, while the plasma VE decreased significantly while the content of VE in liver and RBC did not decrease. After the injury, 2.3μgSe / 100gbw sodium selenite was supplemented every day. The contents of RBC and liver VE were significantly lower than those of the normal control group. The plasma VE was lower than the selenium group without burns and the plasma total sulfhydryl content was more obviously decreased. The results show that selenium supplementation after burn can make the consumption of VE increase.