特发性醛固酮增多症的特点是高血压、低血钾、二侧肾上腺分泌醛固酮过多、血浆肾素受抑制。但醛固酮增多的机理不明。有人推测可能有一种受中枢神经递质控制来自中枢神经或垂体的促醛固酮分泌的物质存在,因而引起肾上腺增生。作者推测此种促醛固酮分泌物质可能受血清素的调节。为验证这一假设,作者对14例醛固酮增多症病人(包括6例双侧特发性增生,8例肾上腺腺瘤),以及5例限钠后醛固酮升高的正常人进行了比较。赛庚啶是一种抗 Idiopathic aldosteronism is characterized by hypertension, hypokalemia, hyperandrogenism on both sides of the adrenal gland, and inhibition of plasma renin. However, the mechanism of increased aldosterone is unknown. It is speculated that there may be a CNS neurotransmitter from the central nervous or pituitary pro-aldosterone secretion of substances, which led to adrenal hyperplasia. The authors hypothesize that such pro-aldosterone-secreting substances may be regulated by serotonin. To test this hypothesis, the authors compared 14 patients with aldosteronism (including 6 cases of bilateral idiopathic hyperplasia, 8 cases of adrenal adenoma) and 5 cases of normal subjects with elevated sodium aldosterone. Cyproheptadine is an anti-inflammatory