西班牙科学研究委员会Gustavo等的最新研究发现,他汀类药物不仅具有降低胆固醇和减少心脏病危险的作用,还可能有助于减慢1型人类免疫缺陷病毒(HIV-1)的感染进程。 HIV-1的感染需要脂质筏相关受体的作用,而在细胞膜胆固醇低的培养细胞中,感染HIV的可能性较小。因此,研究者尝试采用降胆固醇药物来治疗HIV感染。他们首先在细胞和小鼠中证明了他汀类药物的抗HIV疗效,然后对6例未接受高效抗 Recent research by Gustavo et al. Of the Spanish Scientific Research Council found that statins not only have the potential to lower cholesterol and reduce the risk of heart disease, but may also help slow the progression of HIV-1 infection. Infection with HIV-1 requires lipid raft-related receptors, whereas in cultured cells with low cholesterol in the cell membrane, HIV infection is less likely. Therefore, researchers try to use cholesterol-lowering drugs to treat HIV infection. They first demonstrated the anti-HIV efficacy of statins in cells and mice, and then tested 6 patients who did not receive high-potency