已知嘌呤核苷、核苷酸以及环化核苷酸可调节淋巴细胞及其它类型细胞的活性。当鸟嘌呤核糖核苷第八位碳原子用溴或巯基取代后,不仅可作为B 细胞刺激剂的替代物诱导B 细胞增殖和分化,还可对巨噬细胞和NK 细胞起作用。如8-巯基鸟嘌呤核苷(8MG),能取代产生MHC 限制性CTL 所需的细胞因子,并可诱导巨噬细胞分泌IL-1样的物质。本文作者用4小时~(51)Cr 释放试验研究了 Purine nucleosides, nucleotides and circularized nucleotides are known to regulate the activity of lymphocytes and other types of cells. When the eighth carbon atom of guanosine riboside is substituted with bromine or thiol, it can not only induce the proliferation and differentiation of B cells but also act on macrophages and NK cells as an alternative to B cell stimulants. Such as 8-mercaptoguanosine (8MG), can replace the cytokines required to produce MHC-restricted CTLs and can induce macrophages to secrete IL-1-like substances. The authors used 4 hours ~ (51) Cr release test study