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目的:观察茴香枳术汤对大鼠粘连性肠梗阻腹部立位平片的影响,为深入探讨茴香枳术汤对粘连性肠梗阻的作用机制提供实验依据。方法:制备大鼠粘连性肠梗阻模型,随机分为正常组、模型组、大承气汤组、茴香枳术汤低、中、高剂量组。正常组和模型组两组灌服生理盐水0.01 mL·g-1,DS组灌服1.43 g·mL-1大承气汤0.01 mL·g-1,HX-SL,HX-SM,HX-SH 3组分别灌服1.13,2.25,3.38 g·mL-1的茴香枳术汤汤液0.01 mL·g-1。给予相应药物治疗,分别于治疗后第3,5,7天,共3个时间点,每时间点6只;腹腔麻醉后,拍摄腹部立位X线平片,观察肠梗阻的变化。结果:与正常组比较,模型组大鼠有大量积气积液,可见明显的气液平面,肠管扩张;与模型组比较,大承气汤组、茴香枳术汤低剂量组、茴香枳术汤中剂量组和茴香枳术汤高剂量组积气积液消失,肠管恢复正常,气液平面消失,肠梗阻缓解。结论:茴香枳术汤具有良好的治疗粘连性肠梗阻的作用。
OBJECTIVE: To observe the effect of fenghuantuzhu decoction on the abdominal plain film of adhesive intestinal obstruction in rats, and to provide an experimental basis for further study on the action mechanism of fenghuang zhizhu decoction on adhesive intestinal obstruction. Methods: The model of adhesive intestinal obstruction was prepared and divided into normal group, model group, Dachengqi Decoction group, fenghuang zhizhu decoction low, medium and high dose group. The rats of normal group and model group were fed with normal saline (0.01 mL · g-1), DS group were fed with 1.43 g · mL-1 Dachengqi Decoction 0.01 mL · g-1, HX-SL, HX-SM and HX-SH Three groups were fed with 1.13,2.25,3.38 g · mL-1 fennel Zhizhu Decoction solution 0.01 mL · g-1. At the 3rd, 5th, 7th day after treatment, there were 6 time points at each time point. After the abdominal cavity was anesthetized, the plain radiographs of abdomen were taken to observe the change of intestinal obstruction. Results: Compared with the normal group, there was a large amount of accumulative fluid in the model group rats, showing obvious gas-liquid level and intestine dilatation. Compared with the model group, Dachengqi decoction group, fenghuang zhuzhu decoction low dose group, The middle-dose group and fenghuang shengzhu decoction high-dose group disappeared, the intestine recovered, the gas-liquid level disappeared, and the intestinal obstruction relieved. Conclusion: Fen Zhi Zhizhu Decoction has a good treatment of adhesive intestinal obstruction.