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目的观察多西紫杉醇、奥沙利铂(L-OHP)联合5-氟尿嘧啶治疗晚期胃癌的近期疗效及其不良反应。方法对入选的32例晚期胃癌患者以多西紫杉醇、奥沙利铂(L-OHP)、联合5-氟尿嘧啶全身化疗,所有病例均完成4周期后评价疗效。结果32例晚期胃癌患者完全缓解7例,部分缓解14例。总有效率为65,6%。不良反应主要为骨髓抑制和胃肠道反应等,所有患者均未因不良反应中断或退出治疗,结论多西紫杉醇、奥沙利铂(L-OHP)联合5-氟尿嘧啶治疗晚期胃癌近期疗效好,不良反应较轻,值得临床推广。
Objective To observe the short-term efficacy and side effects of docetaxel, oxaliplatin (L-OHP) and 5-fluorouracil in the treatment of advanced gastric cancer. Methods Thirty-two patients with advanced gastric cancer were treated with docetaxel, oxaliplatin (L-OHP) and 5-fluorouracil, and all the patients were evaluated after 4 cycles. Results 32 patients with advanced gastric cancer were completely relieved in 7 patients and partially relieved in 14 patients. The total effective rate is 65,6%. Adverse reactions were mainly myelosuppression and gastrointestinal reactions, all patients were not interrupted or withdrawn from treatment due to adverse reactions. Conclusions Docetaxel, oxaliplatin (L-OHP) and 5-fluorouracil are effective in the treatment of advanced gastric cancer, Minor adverse reactions, it is worth clinical promotion.