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应用碱性磷酸酶-抗碱性磷酸酶(APAAP)方法,对接受培养的人胚胸腺和脾脏移植的34例肿瘤病人分别在移植前1周和移植后10天、3个月进行外周血T细胞亚群检测,并与40例健康人做对照。结果表明,移植前CD_3、CD_4和CD_4/CD_3比值明显低于对照组;与移植前比较,移植后10天上述三项均明显增高(P均<0.01);移植后3个月CD_4明显增高,DD_3、CD_4/CD_3比值增高(P<0.05)。说明移植可改善肿瘤病人免疫功能,并间接证明移植物能存活。
Using alkaline phosphatase-anti-alkaline phosphatase (APAAP) method, Thirty-four tumor patients undergoing cultured human embryonic thymus and spleen were subjected to peripheral blood T at 1 week before transplantation and 10 days and 3 months after transplantation, respectively. Cell subsets were tested and compared with 40 healthy people. The results showed that the ratios of CD3, CD4, and CD4/CD3 before transplantation were significantly lower than those of the control group. Compared with the pretransplantation, the above three items were significantly increased at 10 days after transplantation (P<0.01); CD4 was significantly increased at 3 months after transplantation. The ratio of DD_3 and CD_4/CD_3 increased (P<0.05). It shows that transplantation can improve the immune function of tumor patients and indirectly prove that the graft survives.