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目的探讨P16和P53蛋白表达在宫颈癌发生发展中的意义。方法收集92例手术切除宫颈癌标本,同时取50例正常宫颈组织,应用免疫组化检测宫颈癌组织及正常组织中的P16和P53蛋白表达。结果P16、P53蛋白在正常宫颈组织中的表达率为98%(49/50)、0(0/50),而在宫颈癌的表达分别为54.3%(50/92)、58.7%(54/92)(P<0.05);经统计学比较P16和P53蛋白表达在宫颈中呈负相关(P<0.01)。结论联合检测宫颈癌组织中P16和P53蛋白的表达,是综合判断宫颈癌恶性程度和预后的重要指标。
Objective To investigate the significance of P16 and P53 protein expression in the development of cervical cancer. Methods 92 cases of cervical cancer specimens were collected for surgical resection, and 50 cases of normal cervical tissues were collected. The expression of P16 and P53 protein in cervical cancer tissues and normal tissues was detected by immunohistochemistry. Results The positive rates of P16 and P53 in normal cervical tissue were 98% (49/50) and 0 (0/50), respectively, while those in cervical cancer were 54.3% (50/92) and 58.7% (54 / 92) (P <0.05). There was a negative correlation between the expression of P16 and P53 in the cervix (P <0.01) by statistical analysis. Conclusions Combined detection of P16 and P53 protein expression in cervical cancer is an important index for judging the malignant degree and prognosis of cervical cancer.