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目的 观察前列腺素E1(PGE1)治疗不稳定性心绞痛 (UA)的疗效及安全性。方法 对 30例UA病人使用PGE1180 μg/d治疗 ,15d为 1个疗程。对照组使用杏丁注射液 2 0ml/d治疗 ,15d为 1个疗程。观察两组病人心绞痛缓解情况及心电图、超声心动图、血脂等治疗前后的变化并进行统计分析。结果 PGE1缓解心绞痛总有效率为 80 % ,其结果优于对照组 ,差异有显著意义 (P <0 0 1) ,且病人左室功能得到改善 ,血脂亦明显下降 ,治疗前后对比差异有显著意义 (P <0 0 1)。结论 PGE1可有效治疗UA。
Objective To observe the efficacy and safety of prostaglandin E1 (PGE1) in the treatment of unstable angina pectoris (UA). Methods 30 UA patients treated with PGE1180 μg / d, 15 days for a course of treatment. The control group using Xingding injection 20ml / d treatment, 15d for a course of treatment. The relief of angina pectoris and changes of ECG, echocardiography and blood lipids before and after treatment were observed and statistically analyzed. Results The total effective rate of PGE1 relieving angina pectoris was 80%. The result was better than that of control group (P <0.01), and the left ventricular function was improved and the blood lipids were also decreased significantly, with significant difference before and after treatment (P <0 0 1). Conclusion PGE1 can effectively treat UA.