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目的探讨神经元特异性烯醇化酶(NSE)在颅内感染患儿脑脊液和血清中含量变化及其对化脓性脑膜炎、病毒性脑膜炎的临床意义。方法选择该院2014年1月—2017年1月收治的颅内感染患儿50例与非神经系统感染患儿30例进行对照研究,其中50例颅内感染患儿又分为化脓性脑膜炎(28例)与病毒性脑膜炎(22例),所有患儿均进行脑脊液、血清可溶性白细胞介素2受体(SIL-2R)与NSE水平,并采取统计学分析对相关数据进行处理。结果三组患儿血清、脑脊液中SIL-2R与NSE水平与非神经系统感染患儿比较差异均有统计学意义(P<0.05),同时化脓性脑膜炎患儿血清与脑脊液中SIL-2R与NSE水平要显著高于病毒性脑膜炎患儿(P<0.05)。结论 NSE应用在颅内感染患儿脑脊液与血清中含量有一定差异,尤其是与非神经系统感染患儿相比差异明显,同时化脓性脑膜炎与病毒性脑膜炎患儿在脑脊液、血清中也存在NSE差异,从而可为临床诊断鉴别这二种疾病提供参考依据,值得借鉴。
Objective To investigate the changes of neuron-specific enolase (NSE) in cerebrospinal fluid and serum of children with intracranial infection and its clinical significance in purulent meningitis and viral meningitis. Methods Fifty children with intracranial infection and 30 children with non-neurological infection admitted to our hospital from January 2014 to January 2017 were enrolled in this study. Fifty children with intracranial infection were divided into purulent meningitis (N = 28) and viral meningitis (n = 22). All children underwent cerebrospinal fluid (CSF), serum soluble interleukin 2 receptor (SIL-2R) and NSE levels. Statistical data were used to analyze the data. Results The levels of SIL-2R and NSE in serum and cerebrospinal fluid in three groups were significantly different from those in non-nervous system (P <0.05). In addition, the levels of SIL-2R in serum and cerebrospinal fluid of children with purulent meningitis NSE levels were significantly higher in children with viral meningitis (P <0.05). Conclusion NSE application in children with intracranial infection of cerebrospinal fluid and serum levels have some differences, especially in children with non-nervous system infection significant differences, while purulent meningitis and viral meningitis in children with cerebrospinal fluid, serum NSE differences exist, which can provide a reference for the clinical diagnosis of these two diseases, it is worth learning.