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目的观察固本化积汤联合化疗治疗晚期非小细胞肺癌的近期疗效。方法将194例晚期非小细胞肺癌患者随机分为2组。治疗组102例采用固本化积汤(每日1剂,1个月为1个疗程,共治疗3个疗程)配合化疗(NP或VP方案,3周为1个疗程,共治疗3个疗程)治疗。对照组92例单纯予化疗,方法同治疗组。观察2组瘤体大小变化、生活质量、体质量、主要症状改善情况及不良反应情况。结果治疗组瘤体变化有效率28.4%,对照组13.0%,2组比较差异有统计学意义(P<0.01);治疗组治疗后卡氏评分与本组治疗前及对照组治疗后比较差异均有统计学意义(P<0.01);对照组治疗后体质量与本组治疗前及治疗组治疗后比较差异均有统计学意义(P<0.01);治疗组预后情况、症状改善情况均优于对照组(P<0.05,P<0.01)。治疗组不良反应情况少于对照组(P<0.05,P<0.01)。结论固本化积汤联合化疗治疗晚期非小细胞肺癌近期疗效优于单纯化疗,可作为晚期非小细胞肺癌的有效治疗方案。
Objective To observe the short-term curative effect of Gubenghuji Decoction combined with chemotherapy on advanced non-small cell lung cancer. Methods 194 patients with advanced non-small cell lung cancer were randomly divided into two groups. Treatment group of 102 patients with solidified soup (1 day, 1 month for a course of treatment, a total of 3 courses) with chemotherapy (NP or VP regimen, 3 weeks for a course of treatment, a total of 3 courses )treatment. The control group of 92 patients were given chemotherapy alone, the same way as the treatment group. The changes of tumor size, quality of life, body weight, the improvement of the main symptoms and the adverse reactions were observed. Results The effective rate of tumor in the treatment group was 28.4% and that of the control group was 13.0%, there was significant difference between the two groups (P <0.01). The difference between the treatment group and the control group after treatment (P <0.01). The body weight of the control group after treatment was significantly lower than that before treatment and after treatment in the treatment group (P <0.01). The prognosis and the improvement of the symptoms in the treatment group were better than those in the treatment group Control group (P <0.05, P <0.01). Adverse reactions in the treatment group were less than those in the control group (P <0.05, P <0.01). Conclusion Gubenghuang combined with chemotherapy for advanced non-small cell lung cancer is better than chemotherapy in the short term, which can be used as an effective treatment for advanced non-small cell lung cancer.