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目的研究维格列汀联合二甲双胍治疗2型糖尿病老年患者的临床疗效。方法法选取符合2型糖尿病诊断标准的60岁以上老年患者120例,按双盲法随机分为治疗组(60例),采用维格列汀联合二甲双胍治疗及对照组(60例)采用二甲双胍加安慰剂治疗,半年后观察对比分析两组患者的情况。结果治疗前无差异,治疗半年后,治疗组在FBG、2hPG、HbA1c及BMI方面明显低于对照组(P<0.05),而不良反应发生率在两组间没有明显差异。结论维格列汀联合二甲双胍对于治疗老年2型糖尿病有较好的疗效。
Objective To investigate the clinical efficacy of veglnitidine combined with metformin in elderly patients with type 2 diabetes. METHODS: One hundred and twenty elderly patients over 60 years old, who were diagnosed as type 2 diabetes mellitus, were selected and randomly divided into treatment group (60 cases) by double-blind method, metformin combined with metformin and control group (60 cases) Placebo treatment, six months after the observation and comparison of two groups of patients. Results There was no difference before treatment. After six months of treatment, the treatment group showed significantly lower FBG, 2hPG, HbA1c and BMI than the control group (P <0.05). The incidence of adverse reactions was not significantly different between the two groups. Conclusion Vildagliptin combined with metformin has a good effect on the treatment of type 2 diabetes in the elderly.