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目的 :探讨中药循经敷贴治疗哮喘的作用机理。方法 :采用Hutson法豚鼠模型 ,治疗组隔日诱喘后用中药敷贴30min ,对照组诱喘后隔日采用 0 .9%氯化钠溶液浸润纱布敷贴 ,比较记录诱喘潜伏期时间。 2周后处死 ,取肺组织 ,用放射配基竞争结合法比较β受体含量。结果 :中药循经敷贴能显著延长哮喘豚鼠诱喘潜伏期 ,减轻发作程度 ,上调哮喘豚鼠肺组织β受体含量。结论 :二次实验结果提示 ,提高β受体含量是中药循经敷贴治疗哮喘的重要机制之一。
Objective : To explore the mechanism of traditional Chinese medicines in the treatment of asthma. METHODS: The Hutson guinea pig model was used. The treatment group was treated with traditional Chinese medicine for 30 minutes after asthma induction every other day. The control group was treated with 0.1% sodium chloride solution on the next day after inhalation. The incubation period was compared. Two weeks later, the lung tissue was sacrificed and the beta-receptor content was compared by radioligand competition binding assay. RESULTS : Traditional Chinese medicine application can significantly increase asthmatic guinea pigs’ incubation period, reduce the degree of attack, and up-regulate β-receptor levels in lung tissue of asthmatic guinea pigs. Conclusion : The results of the second experiment suggest that increasing β-receptor content is one of the important mechanisms by which traditional Chinese medicine is applied to treat asthma.