论文部分内容阅读
低氧诱导因子-1(HIF-1)是一种调控组织细胞氧稳态的关键性核转录因子,广泛存在于哺乳动物和人体内,其表达和活性受到细胞氧浓度的严密调控。它能在生理性和病理性缺氧缺血的情况下,通过调控细胞能量代谢、血管发生、红细胞生成、细胞生存、细胞增殖和凋亡等生物学效应,使细胞适应低氧环境得以生存或者走向凋亡。本文中我们主要概述了HIF-1的结构功能,及其在缺氧时调控骨骼肌能量代谢方面发生适应性变化的机制及研究进展。
Hypoxia-inducible factor-1 (HIF-1) is a key nuclear transcription factor that regulates the homeostasis of tissue cells. It is widely found in mammals and humans, and its expression and activity are closely regulated by cellular oxygen concentrations. It can adapt to the hypoxic environment to survive or not through physiological effects such as energy metabolism, angiogenesis, erythropoiesis, cell survival, cell proliferation and apoptosis under physiological and pathological hypoxic-ischemic conditions or Go to apoptosis. In this paper, we mainly summarize the structural function of HIF-1 and its mechanism of adaptive changes in the regulation of skeletal muscle energy metabolism during hypoxia and its research progress.