Objective: To determine if there is a relationship between parental perception of neighborhood safety and overweight at the age of 7 years. Design: Cross-sec tional analysis of the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development. Setting: Ten urban and rural US sites. Participants: A total of 768 children selected via conditional random sa mplingwith complete data at follow-up. Main Outcome Measures: Parents reported demographics and perception of neighborhood safety by standardized questionnaire . Child overweight status was defined as a body mass index greater than or equal to the 95th percentile for age and sex from measured anthropometrics at the age of 7 years. The base model included relationship of the safety reporter to the child, sex, and baseline body mass index z score at the age of 4.5 years. Covari ates tested included maternal marital status, education, and depressive symptoms ; child race/ethnicity; participation in structured after-school activities; Ho me Observation for Measurement of the Environment total score; and neighborhood social cohesiveness. Results: The sample was 85%white, and 10%of the children were overweight. Neighborhood safety ratings in the lowest quartile were indepen dently associated with a higher risk of overweight at the age of 7 years compa red with safety ratings in the highest quartile (adjusted odds ratio, 4.43; 95%confidence interval, 2.03-9.65) . None of the candidate covariates altered the relationship between perception o f neighborhood safety and child overweight status. Conclusions: Perception of th e neighborhood as less safe was independently associated with an increased risk of overweight at the age of 7 years. Public health efforts may benefit from poli cies directed toward improving both actual and perceived neighborhood safety. Objective: To determine if there is a relationship between parental perception of neighborhood safety and overweight at the age of 7 years. Design: Cross-sec tional analysis of the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development. Setting: Ten urban and rural US sites. Participants: A total of 768 children selected via conditional random sa mplingwith complete data at follow-up. Main Outcome Measures: Parents reported demographics and perception of neighborhood safety byONOMality questionnaire. Child overweight status was defined as a body mass index greater than or equal to the 95th percentile for age and sex from measured anthropometrics at the age of 7 years. The base model included relationship of the safety reporter to the child, sex, and baseline body mass index z score at the age of 4.5 years. Covari ates tested included maternal marital status, education, and depressive symptoms; child race / ethnicity; participation i Results: The sample was 85% white, and 10% of the children were overweight. Neighborhood safety ratings in the lowest quartile were indepen dently associated with a higher risk of overweight at the age of 7 years compa red with safety ratings in the highest quartile (adjusted odds ratio, 4.43; 95% confidence interval, 2.03-9.65). None of the candidate covariates altered the relationship between perception of neighborhood safety and child overweight status. Conclusions: Perception of th e neighborhood as less safe was dependent associated with an increased risk of overweight at the age of 7 years. Public health efforts may benefit from poli cies directed toward improving both actual and perceived neighborhood safety.