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氢键诱导的线性芳酰胺寡聚体骨架可以采取折叠、螺旋、直线或“之”字型构象.这一结构预组织特征可以被应用于促进大环的合成.在芳酰胺骨架的两端引入适当反应基团,骨架的预组装构象可以诱导它们形成不同的空间取向和距离.当成环反应涉及到不可逆共价键、碳-金属键或配位键的形成时,前体的结构预组织构象可以促进目标大环形成的产率.当成环反应涉及亚胺及腙等可逆共价键时,在反应达到热力学平衡后,可以高产率或定量地形成大环.
Hydrogen bond-induced linear aromatic amide oligomer skeletons can take the form of folded, helical, straight or “” structure. This structure of the pre-organizational features can be applied to promote the synthesis of macrocycles in the aromatic amide skeleton of the two When the ring-closure reaction involves the formation of irreversible covalent bonds, carbon-metal bonds or coordination bonds, the structure of the precursors pre-assembled Tissue conformation can promote the yield of the target macrocycle.When the ring reaction involves a reversible covalent bond, such as imine and hydrazone, the macrocycle can be formed with high yield or ration after the reaction reaches the thermodynamic equilibrium.