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目的:探讨百令胶囊辅助治疗对过敏性紫癜性肾炎(HSPN)患儿尿单核细胞趋化蛋白-1(MCP-1)、尿微量蛋白(m Alb)及24h尿蛋白定量(Up)水平的影响。方法:64例HSPN患儿随机分为普通组与百令组各32例。普通组给予常规激素、潘生丁、氯雷他定等治疗,百令组在此基础上加用百令胶囊0.4~0.6 g,po,tid。疗程均为4周。观察两组患儿治疗前后尿MCP-1、m Alb及24h Up水平的变化。结果:治疗4周后,两组患儿尿MCP-1、m Alb及24h Up均较治疗前下降(P<0.05),且百令组较普通组下降更显著(P<0.05)。结论:百令胶囊辅助治疗HSPN,能显著减少蛋白尿,改善肾功能。
Objective: To investigate the effect of Bailing capsule on urinary monocyte chemoattractant protein-1 (MCP-1), urinary microalbumin (m Alb) and 24h urinary protein in children with hereditary HSPN.Methods: Impact. Methods: Sixty-four children with HSPN were randomly divided into normal group and Bailing group, with 32 cases each. Common group given conventional hormones, dipyridamole, loratadine and other treatment, Bailing group on this basis with Bailing capsule 0.4 ~ 0.6 g, po, tid. The course of treatment is 4 weeks. The changes of urinary MCP-1, m Alb and 24h Up before and after treatment in both groups were observed. Results: After 4 weeks of treatment, the urinary MCP-1, m Alb and 24h Up in both groups were significantly lower than those before treatment (P <0.05). Conclusion: Bailing Capsule adjuvant treatment of HSPN can significantly reduce proteinuria and improve renal function.