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目的 :探讨妊娠期甲亢患者血清甲状腺免疫含量及甲状腺功能的相关变化,为临床及早诊断与治疗提供依据。方法 :选择60例妊娠期甲亢患者为观察组,同期90例妊娠期非甲亢患者为对照组。结果 :妊娠早期,观察组患者T4、T3及TRAb阳性率高于对照组,差异存在统计学意义。妊娠中期,观察组患者T4、T3及TRAb阳性率均高于对照组,FT4及FT3低于对照组,差异存在统计学意义。妊娠晚期,观察组患者T4、T3高于对照组,FT4及FT3低于对照组,差异存在统计学意义。结论 :妊娠期甲亢患者血清甲状腺免疫含量及甲状腺功能在妊娠早、中、晚期均存在明显的改变,临床工作中应该定期检查以早期诊断和治疗。
Objective: To investigate the changes of serum thyroid immune volume and thyroid function in patients with hyperthyroidism during pregnancy, and provide the basis for early clinical diagnosis and treatment. Methods: 60 cases of hyperthyroidism during pregnancy were selected as the observation group. 90 pregnant women with non-hyperthyroidism during the same period were selected as the control group. Results: The positive rate of T4, T3 and TRAb in observation group was higher than that in control group in early pregnancy, the difference was statistically significant. In the second trimester, the positive rates of T4, T3 and TRAb in the observation group were higher than those in the control group, FT4 and FT3 were lower than the control group, the difference was statistically significant. In the third trimester of pregnancy, T4 and T3 in the observation group were higher than those in the control group, FT4 and FT3 were lower than the control group, the difference was statistically significant. Conclusion: Serum thyroid immunization and thyroid function in patients with hyperthyroidism during pregnancy have obvious changes in early, middle and late pregnancy, and should be checked regularly for early diagnosis and treatment in clinical work.