In oil and gas exploration and transportation,low dosage hydrate inhibitors(LDHIs) are more favorably utilized to inhibit the formation of hydrates than thermodynamic inhibitors(THs) as a trend. However,there are no industrial products of LDHIs available domestically,and the corresponding application experience is in urgent need. In this paper,a combined hydrate inhibitor(HY-1) was synthesized after a series of reaction condition optimization,and its performance on THF hydrate inhibition was investigated using kinetic hydrate inhibitor evaluation apparatus with 6 cells bathing in air. The results show that when the reaction temperature is 60°C,the reaction time is 6 h,and the monomer:solvent ratio is 1:2,the product has the best kinetic hydrate inhibitor performance on THF hydrate. On these bases,the scale-up production of this combined hydrate inhibitor was carried out. Although the scale-up product(HY-10) performs less effectively on the THF hydrate inhibition than HY-1,it functions better than a commercial product(Inhibex501) during in-house tests. HY-10 was successfully applied to the gas production process. Field trials in northern Shaanxi PetroChina Changqing Oilfield Company(PCOC) show that 2 wt% of HY-10 is effective on natural gas hydrate inhibition. It is found through economic analysis that the use of HY-10 has obvious economical advantage over methanol and Inhibex501. In oil and gas exploration and transportation, low dosage hydrate inhibitors (LDHIs) are more favorably utilized to inhibit the formation of hydrates than thermodynamic inhibitors (THs) as a trend. However, there are no industrial products of LDHIs available domestically, and the corresponding In this paper, a combined hydrate inhibitor (HY-1) was synthesized after a series of reaction condition optimization, and its performance on THF hydrate inhibition was investigated using kinetic hydrate inhibitor evaluation apparatus with 6 cells bathing in air. The results show that when the reaction temperature is 60 ° C, the reaction time is 6 h, and the monomer: solvent ratio is 1: 2, the product has the best kinetic hydrate inhibitor performance on THF hydrate. On these bases, the scale-up production of this combined hydrate inhibitor was carried out. The scale-up product (HY-10) performs less efficient on the THF hydrate inhibition than HY-1, it functions HY-10 was successfully applied to the gas production process. Field trials in northern Shaanxi PetroChina Changqing Oilfield Company (PCOC) show that 2 wt% of HY-10 is effective on natural gas hydrate inhibition. It is found through economic analysis that the use of HY-10 has obvious economical advantage over methanol and Inhibex501.