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本文研究单剂和连续服用ACE抑制剂西拉普利(Cilazapril,CIL)对肾功能正常(NRF)和减退(IRF)的高血压患者的降压效果和药动学。方法:12例高血压患者,其中5例为NRF,7例IRF(未血透),两组有可比性。研究前停用抗高血压药至少5天,CIL治疗时禁用任何药物。在卧床休息1小时后(隔晚空腹),所有病人单剂口服CIL 1.25mg,第2天再口服CIL 1.25mg每日1次,连续4～7天。给药前、单剂给药后和连续给药最后一天分别定时记录血压和脉率,并收集血、尿,
This article investigates the antihypertensive efficacy and pharmacokinetics of Cilazapril (CIL), a single dose and continuous administration of ACE inhibitor, in hypertensive patients with normal renal function (NRF) and diminished IRF. Methods: Twelve hypertensive patients, including 5 cases of NRF, 7 cases of IRF (hemodialysis), the two groups were comparable. Antihypertensives were discontinued for at least 5 days prior to the study and any drug was disabled during CIL treatment. One hour after bed rest (fasting late every other day), all patients received a single oral CIL 1.25mg, the second day of CIL 1.25mg once daily for 4 to 7 days. Before administration, single-dose administration and continuous administration of the last day of blood pressure and pulse rate were recorded, and collected blood, urine,