目的　探讨口腔粘膜恶性黑色素瘤的有效治疗手段。方法　回顾分析 3 5例患者的临床资料。结果　全组总的 5年生存率为 2 8.6% ,其中化疗组为 0 ,原发灶扩大切除加化疗组为 3 0 .8% ,原发灶扩大切除加颈淋巴清扫加化疗组为 40 .0 %。结论　以原发灶扩大切除加颈淋巴清扫为主的综合治疗仍为目前治疗口腔粘膜恶性黑色素瘤的有效手段。 Objective To investigate the effective treatment of oral mucosal malignant melanoma. Methods The clinical data of 35 patients were retrospectively analyzed. Results The overall 5-year overall survival rate was 22.6%, of which 0 was in the chemotherapy group, 30.8% in the primary resection and chemotherapy group, and the primary tumor was enlarged and resected in addition to the neck dissection plus chemotherapy group. 0%. Conclusions The combined treatment of enlarged primary resection plus cervical lymph node dissection is still an effective method for the treatment of oral mucosal malignant melanoma.