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目的:分析妊娠期肝功能异常的分娩结局,评估单纯性肝功能异常和妊娠期肝内胆汁淤积症对孕产妇和围产儿的影响。方法:选取单纯性肝功能异常的孕妇169例,妊娠期肝内胆汁淤积症61例为研究组,同期正常孕妇100例为对照组,比较3组孕妇的妊娠结局。结果:肝功能异常2组与对照组合并乙肝病毒感染,3组对比差异无统计学意义。肝功能异常2组剖宫产率与对照组相比有统计学差异。尤以ICP组为明显,剖宫产原因胎儿宫内窘迫占51.2%。ICP组新生儿窒息率、重度窒息率及死胎、死产率均明显高于单纯性肝功能异常组及对照组。结论:加强孕期监护,及时发现肝功能异常,尤其是妊娠期肝内胆汁淤积症,适时终止妊娠可降低围产儿死亡率。
OBJECTIVE: To analyze the delivery outcomes of abnormal liver function during pregnancy and evaluate the effects of simple liver dysfunction and intrahepatic cholestasis of pregnancy on pregnant women and perinatals. Methods: 169 pregnant women with abnormal liver function abnormalities, 61 cases of intrahepatic cholestasis of pregnancy were selected as the study group, and 100 normal pregnant women as the control group during the same period. The pregnancy outcomes of the 3 groups of pregnant women were compared. Results: There was no significant difference between the two groups in the control group and the control group with hepatitis B virus infection. There were significant differences between the two groups in the rate of cesarean section and the control group. Especially in the ICP group, cesarean section causes fetal distress accounted for 51.2%. The incidence of neonatal asphyxia, severe asphyxia, stillbirth and stillbirth in ICP group were significantly higher than those in simple hepatic dysfunction group and control group. Conclusion: To strengthen monitoring of pregnancy, timely detection of abnormal liver function, especially in pregnancy intrahepatic cholestasis, timely termination of pregnancy can reduce perinatal mortality.