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血小板在原位血栓形成过程中起着重要作用。本文将血液离散为具有血浆和血小板特性的粒子,根据原位血栓的生理形成过程提出了壁面吸附的血小板与被吸附的血小板间的吸附作用力模型,使用移动粒子半隐式方法(MPS)模拟了毛细血管受损壁面处血小板聚集形成原位血栓的过程。模拟结果再现了管壁面受损处原位血栓的形成过程,结果显示原位血栓形成过程较快,且血栓一旦形成后血小板数目不再增长。对血小板的速度场进行分析,发现血小板凝聚时经历了对已凝聚血小板粒子的冲击、稳定,最后可能脱落的过程。和水平受损壁面处相比,弯曲受损壁面处原位血栓形成较慢。
Platelets play an important role in the process of in situ thrombosis. In this paper, blood is separated into particles with plasma and platelet properties. According to the physiological process of in situ thrombus, a model of adsorptive force between adsorbed platelets and platelets adsorbed on the wall is proposed, and the model is simulated by moving particles semi-implicit method (MPS) The process of platelet aggregation at the damaged capillary wall to form an in situ thrombus. The simulation results reproduce the formation of in situ thrombus at the damaged wall of the tube. The results show that the in situ thrombosis process is rapid and the number of platelets does not increase once the thrombus is formed. Platelet velocity field analysis, found that platelet aggregation experienced by the impact of the platelet aggregation, stability, the process may eventually fall off. In-situ thrombosis at the damaged wall is slower than at the level of the damaged wall.