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实验证明,雄性动物或病人心肌梗塞后血清睾酮(Testosterone,T)明显减少,心功能降低。给予T有助于左室功能的恢复。但对其作用机理尤其对心肌线粒体呼吸功能的研究,国内外报道较少,本实验拟从能量代谢角度予以探讨。选健康成年雄性SD大鼠,随机分为正常对照组(NC,n=7);去睾丸组(OR,n=9);去睾丸加睾酮组(OR+T,n=6).OR+T组于摘除性腺后间日肌注丙酸睾丸李玉李玉酮(每次剂量2mg/只)用香油稀释至0.1ml,NC及OR组于相同时间肌注同容量香油,术后3个月同时处死,迅速取其心脏作成匀浆,低温离心,制备线粒
Experiments have shown that serum testosterone (T) is significantly reduced and heart function is reduced in male animals or patients after myocardial infarction. Give T to help restore the left ventricular function. However, there are few reports on its mechanism of action, especially the study of myocardial mitochondrial respiratory function. This experiment is to be discussed from the perspective of energy metabolism. Healthy adult male Sprague-Dawley rats were randomly divided into normal control group (NC, n=7); testis group (OR, n=9); testis plus testosterone group (OR+T, n=6). In the T group, the intramuscular injection of propionic acid testosterone, Li Yu, Li Yu ketone (2 mg per dose) was diluted with sesame oil to 0.1 ml after extirpation of gonads. NC and OR groups were intramuscularly injected with the same volume of sesame oil at the same time. Months were sacrificed at the same time. The heart was quickly homogenized and centrifuged at low temperature to prepare strands.