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目的 探讨卵巢不典型子宫内膜异位症的恶变潜能。方法 观察 12例合并子宫内膜异位症的子宫内膜样卵巢癌手术标本的形态学特点 ,并对各例癌组织和癌旁子宫内膜异位症组织分别采用微卫星标记检测 10q2 3.3部位的杂合子缺失。结果 12例癌旁子宫内膜异位症的形态学观察结果显示 :8例合并嗜酸性上皮化生 ;5例同时有明显的细胞异型性 ,符合不典型子宫内膜异位症 ,并可见与周围癌组织有移行现象。从不典型子宫内膜异位症的病变组织中 ,有 2例检测出与周围癌组织相同位点的基因改变。结论 卵巢的不典型子宫内膜异位症可能是具有恶变潜能的癌前病变。
Objective To investigate the malignant potential of atypical ovarian endometriosis. Methods The morphological features of 12 cases of endometrial-like ovarian cancer with endometriosis were observed. The microscopic markers of 10q2 and 3.3 were detected in each case of cancer tissues and adjacent endometriosis tissues. Of the heterozygotes are missing. Results The morphological observation of 12 cases with adjacent endometriosis showed that 8 cases were complicated with eosinophilic metaplasia, 5 cases with obvious cell atypia and atypical endometriosis, Surrounding cancer tissue migration phenomenon. In atypical endometriosis from diseased tissue, 2 cases detected the same site with surrounding cancer gene changes. Conclusions Atypical endometriosis in ovary may be a precancerous lesion with malignant potential.