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目的探讨急性胰腺炎患者肝功能损害的临床特点及预后。方法对2001-01~2003-10期间第二军医大学长海医院收治的290例急性胰腺炎进行回顾性分析。结果通过对比不同类型急性胰腺炎的肝功能损害和C-反应蛋白(CRP)变化,发现随着胰腺炎病情加重,肝损害明显;且重型急性胰腺炎患者的肝功能损害与CRP有一定相关性(P<0.01)。结论急性胰腺炎合并肝功能损害几率较高,其发生机制可能与全身炎症反应有关。肝脏损害与CRP的变化有一定相关性。
Objective To investigate the clinical features and prognosis of liver injury in patients with acute pancreatitis. Methods A retrospective analysis of 290 cases of acute pancreatitis admitted to Changhai Hospital of the Second Military Medical University from January 2001 to October 2003 was conducted. Results Comparing the changes of hepatic dysfunction and C-reactive protein (CRP) in different types of acute pancreatitis, it was found that with the aggravation of pancreatitis, the liver damage was obvious. And the liver dysfunction in patients with severe acute pancreatitis had some correlation with CRP (P <0.01). Conclusion There is a high risk of acute pancreatitis complicated with liver dysfunction, which may be related to the systemic inflammatory response. Liver damage and changes in CRP have a certain relevance.