组织型纤溶酶原激活剂(t-PA)是一种丝氨酸蛋白酶,使纤溶酶原水解转变成纤溶酶,在纤溶系统中发挥重要的作用。近几年的研究发现t—PA在神经系统中同样有着重要的作用,参与了癫痫、Alzheimer病、脑缺血、坐骨神经损伤等疾病的发生与发展,大脑学习和记忆功能的发挥,神经系统的发育等多种生理和病理过程。t—PA在神经系统中发挥的作用,是一个有多种细胞和分子参与的复杂过程,其机制有许多的未明之处,因此深入研究t—PA多种功能和作用机制有着非常重要的意义。 Tissue-type plasminogen activator (t-PA) is a serine protease, the hydrolysis of plasminogen into plasmin, fibrinolysis system play an important role. In recent years, the study found that t-PA also plays an important role in the nervous system and is involved in the occurrence and development of diseases such as epilepsy, Alzheimer’s disease, cerebral ischemia, sciatic nerve injury, brain learning and memory function, nervous system Development and other physiological and pathological processes. The role of t-PA in the nervous system is a complicated process involving many kinds of cells and molecules. Its mechanism has many uncertainties. Therefore, it is very important to study the various functions and mechanisms of t-PA .