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目的 :探析C反应蛋白(CRP)在伴高脂血症的老年急性胰腺炎(HLAP)严重程度评估中的重要作用。方法 :分析2010年4月~2015年4月在我院接受治疗的48例老年HLAP患者的临床资料。根据老年HLAP患者的严重程度将入选者分成MAP组(28例)和SAP组(18例)两组。比较两组患者的基线资料、胆固醇(CHOL)、血清甘油三酯(TG)和CRP以及治疗前后CT、Ranson、APACHE评分。结果 :两组患者在基线资料间的差异无统计学意义。SAP组的CRP及TG水平均明显高于MAP组;两组患者的CHOL无统计学差异。所有患者在接受2-3次的血液滤过和血脂吸附治疗后,用降脂药和强化胰岛素等进行辅助治疗,基本将血脂降至正常范围内,比较治疗前、治疗后的CT、Ranson、APACHE评分,发现有统计学差异。结论 :高脂血症(HL)是AP发病的一个危险因子;CRP的检测可以作为评估AP患者病情的严重程度的一个重要指标。
Objective: To investigate the important role of C-reactive protein (CRP) in assessing the severity of senile acute pancreatitis (HLAP) with hyperlipidemia. Methods: The clinical data of 48 elderly HLAP patients who were treated in our hospital from April 2010 to April 2015 were analyzed. According to the severity of senile HLAP patients were divided into MAP group (28 cases) and SAP group (18 cases) two groups. Baseline data, cholesterol (CHOL), serum triglyceride (TG), CRP, and CT, Ranson and APACHE scores before and after treatment were compared between the two groups. Results: There was no significant difference in baseline data between the two groups. The levels of CRP and TG in SAP group were significantly higher than those in MAP group. There was no significant difference in CHOL between the two groups. All patients received 2-3 times of hemofiltration and lipids adsorption therapy, with lipid-lowering drugs and insulin-intensive treatment of adjuvant therapy, the basic lipid levels fell to the normal range, before treatment, after treatment of CT, Ranson, APACHE score, found to have statistical differences. Conclusion: Hyperlipidemia (HL) is a risk factor for AP. The detection of CRP can be used as an important index to evaluate the severity of AP patients.