论文部分内容阅读
目的探讨低分子肝素应用于不稳定性心绞痛的安全性和有效性。方法将2009年1月～2009年9月入住我院心血管病房的100例患者随机分为试验组(50例)和对照组(50例),对照组常规抗心绞痛治疗加用普通肝素,治疗组在常规抗心绞痛治疗的基础上加用低分子肝素钠,观察比较两组的疗效及不良反应。结果临床疗效治疗组总有效率为94.0%,对照组总有效率78.0%,两组比较有显著性差异(p<0.05)。治疗组的心电图改善情况与对照组相比,差异具有统计学意义(p<0.05)。两组血小板聚集率、全血黏度、血浆黏度显著降低(p<0.01),治疗组与对照组比有差异(p<0.05)。治疗过程中,对照组有1例患者穿剌部位渗血,1例患者出现皮下瘀斑,2例患者牙龈出血;治疗组有仅有1例出现注射部位皮下瘀斑,停药后逐渐好转。结论不稳定型心绞痛的治疗上低分子肝素的疗效明显高于普通肝素,并且出血危险性方面优于肝素组,值得推广应用。
Objective To investigate the safety and efficacy of low molecular weight heparin in the treatment of unstable angina pectoris. Methods 100 patients admitted to our hospital ward from January 2009 to September 2009 were randomly divided into experimental group (50 cases) and control group (50 cases). The control group was treated with conventional anti-angina pectoris and unfractionated heparin. On the basis of routine anti-angina treatment, the patients were given low-molecular-weight heparin sodium, and the curative effect and adverse reactions of the two groups were observed and compared. Results The total effective rate of the treatment group was 94.0% and that of the control group was 78.0%. There was significant difference between the two groups (p <0.05). The improvement of electrocardiogram in the treatment group compared with the control group, the difference was statistically significant (p <0.05). The platelet aggregation rate, whole blood viscosity and plasma viscosity decreased significantly in both groups (p <0.01), and there was significant difference between the two groups (p <0.05). In the course of treatment, one patient in the control group had bleeding through the puncture site, one patient had subcutaneous ecchymosis, and two patients had bleeding gums. Only 1 patient in the treatment group had subcutaneous ecchymosis at the injection site, and gradually improved after stopping the treatment. Conclusion The efficacy of low molecular weight heparin on unstable angina pectoris is obviously higher than that of unfractionated heparin, and the bleeding risk is superior to that of heparin group, which is worth popularizing and applying.