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目的运用单光子发射断层扫描仪(SPECT)对比观察不同年龄组正常人执行手指简单运动时脑内不同感兴趣区(ROI)的血流量变化,以期探讨运动功能区的作用。方法健康的志愿者18例,按照年龄划分为青年组和中老年组。每一受试对象分别安静和执行手指简单运动状态下进行99mTcECDSPECT扫描脑血流量测定。结果两组间的运动频率无明显差异,但中老年组的错误率显著高于青年组。运动激活后各脑叶的局部血流量无明显变化,而对侧初级运动区(M1)、同侧小脑、双侧辅助运动区(SMA)血流量显著变化。两组间相比,中老年组的对侧M1、同侧小脑的血流量增加低于年轻组,而双侧SMA则大于青年组(P<0.05)。结论手指的简单运动主要激活对侧M1、同侧小脑、双侧SMA;中老年组的SMA激活比青年组明显,显示中、老年人通过自身代偿机制调动更多的SMA参与运动的启动与执行。
Objective To compare the changes of blood flow in different regions of interest (ROI) of the brain in different age groups with single-photon emission computed tomography (SPECT) in order to explore the role of motor function area. Methods 18 healthy volunteers were divided into young group and middle-aged group according to their age. Each subject was silenced and performed 99mTcECDSPECT scan of cerebral blood flow under simple exercise condition. Results There was no significant difference in the frequency of exercise between the two groups, but the error rate was significantly higher in the middle-aged and elderly groups than in the youth group. There was no significant change in the local blood flow of each lobe after the activation of the motor, while the blood flow in the contralateral primary motor area (M1), ipsilateral cerebellum and bilateral arousal area (SMA) significantly changed. Compared with the young group, the increase of blood flow in the contralateral M1 and ipsilateral cerebellum of the middle-aged group was higher than that of the young group (P <0.05). Conclusion The simple movements of the fingers mainly activate contralateral M1, ipsilateral cerebellum and bilateral SMA. SMA activation in the middle-aged and elderly groups is more obvious than that in the youth group, indicating that the elderly and middle-aged people mobilize more SMA-involved motivation through their own compensatory mechanisms carried out.