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自钙调蛋白(CaM)发现以来,已有许多证据提示它可以调节细胞增殖,并在肿瘤组织中发生了量和质的变化随着CaM阻滞剂的临床试用,有作者认为CaM可能成为化学抗癌治疗剂的新靶体,从而引起了临床肿瘤医生的极大兴趣。CaM在细胞增殖中的作用一、CaM在正常细胞增殖中的作用正常细胞增殖需要钙(Ca~(++)),CaM参与细胞内钙浓度的调节。实验发现,在T_(51)B鼠肝细胞DNA合成初期,培养基中的
Since the discovery of calmodulin (CaM), there has been a lot of evidence suggesting that it can regulate cell proliferation and undergo a quantitative and qualitative change in tumor tissue. With the clinical trial of CaM blockers, the authors believe that CaM may become a chemical The new targets of anticancer therapeutics have caused great interest among clinical oncologists. The Role of CaM in Cell Proliferation 1. The Role of CaM in Normal Cell Proliferation Normal cells require calcium (Ca ++), and CaM participates in the regulation of intracellular calcium concentration. The experiment found that in the initial stage of DNA synthesis of T_(51)B mouse hepatocytes, the