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1例53岁女性患者,为滋补强身自行服用灵芝益寿胶囊4粒,3次/d。2个月后出现尿色深黄。约4个月后出现皮肤、巩膜黄染,上腹部不适,伴有恶心、乏力、倦怠。实验室检查:丙氨酸转氨酶(ALT)1114 U/L,天冬氨酸转氨酶(AST)611 U/L,y-L-谷氨酰转移酶(γ-GT)235 U/L,碱性磷酸酶(ALP)158 U/L,总胆红素(TBil)104.5μmol/L,直接胆红素(DBil)63.2μmol/L,间接胆红素(IBil)41.3μmol/L,总胆汁酸(TBA)165.3μmol/L。诊断:药物性肝损害。停用灵芝益寿胶囊,给予还原型谷胱甘肽、异甘草酸镁及丁二磺酸腺苷蛋氨酸治疗。2周后复查肝功能:ALT 69 U/L,AST 35 U/L,γ-GT 100 U/L,ALP 137 U/L,TBil 30.1μmol/L,DBil 14.4μmol/L,IBil 15.7μmol/L,TBA 70.2μmol/L。
A 53-year-old female patient, for nourishing themselves take Ganoderma Yishou Capsule 4, 3 times / d. 2 months after dark yellow urine. About 4 months after the skin, yellowish sclera, upper abdominal discomfort, accompanied by nausea, fatigue, fatigue. Laboratory tests included alanine aminotransferase (ALT) 1114 U / L, aspartate aminotransferase (AST) 611 U / L, yL-glutamyl transferase 235 U / L, (ALI) 158 U / L, TBIL 104.5 μmol / L, DBil 63.2 μmol / L, IBIL 41.3 μmol / L, total bile acid (TBA) 165.3 μmol / L. Diagnosis: Drug-induced liver damage. Disable Ganoderma Yishou capsules, given reduced glutathione, magnesium isoglycyrrhizinate and adenosine methionine butane disulfonate treatment. Two weeks later, liver function was examined: ALT 69 U / L, AST 35 U / L, γ-GT 100 U / L, ALP 137 U / L, TBil 30.1 μmol / L, DBil 14.4 μmol / L, IBil 15.7 μmol / , TBA 70.2 μmol / L.