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目的:观察茶多酚辅助治疗慢性乙型肝炎的临床效果和安全性。方法:选取2013年11月至2015年4月武汉大学人民医院收治的82例慢性乙型病毒性肝炎患者作为研究对象,随机分为对照组(41例)和观察组(41例)。对照组给予常规抗病毒治疗,观察组在对照组基础上给予茶多酚片。观察两组治疗前后HBeAg、血清HBV-DNA水平、ALT、TBIL、ALP变化及不良反应发生情况,并比较两组疗效。结果:治疗6个月后,两组患者临床症状均有所改善,但观察组总有效率(90.2%)高于对照组的80.5%(P<0.05);两组HBeAg血清转换率、血清HBV-DNA转阴率、ALT、TBIL、ALP均都有所改善,且观察组比对照组变化更明显(P<0.05)。对照组腹泻2例、头晕恶心1例,观察组头晕恶心2例,经调整用药治疗都有所缓解,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:茶多酚辅助治疗慢性乙型肝炎疗效更显著,值得临床推广。
Objective: To observe the clinical effect and safety of tea polyphenols in the treatment of chronic hepatitis B. Methods: 82 patients with chronic hepatitis B who were admitted to Wuhan University People’s Hospital from November 2013 to April 2015 were randomly divided into control group (41 cases) and observation group (41 cases). The control group was given routine antiviral therapy, and the observation group was given the tea polyphenols tablets on the basis of the control group. The levels of HBeAg, serum HBV-DNA, ALT, TBIL, ALP and adverse reactions in the two groups were observed before and after treatment. The curative effect was compared between the two groups. Results: The clinical symptoms of both groups improved after 6 months treatment, but the total effective rate (90.2%) in the observation group was higher than that in the control group (80.5%, P <0.05). The HBeAg seroconversion rate, serum HBV DNA negative rate, ALT, TBIL, ALP all improved, and the observation group changed more obviously than the control group (P <0.05). In the control group, 2 cases of diarrhea, 1 case of dizziness and nausea, 2 cases of dizziness and nausea in the observation group were relieved after adjustment. The incidence of adverse reactions was no significant difference between the two groups (P> 0.05). Conclusion: Tea polyphenols auxiliary treatment of chronic hepatitis B more significant effect, worthy of clinical promotion.