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目的评价拉莫三嗪治疗成人部分性发作癫癎的临床疗效与安全性。方法收集成人部分性发作癫癎患者89(76)例,分别给予拉莫三嗪单药、替换或添加治疗,进行开放性自身对照研究,随访24周发作情况,登记监测不良反应。结果 89例中76例完成终点试验,总有效率为82.8%,平均起效剂量为(99.7±18.6)mg/d,平均起效时间为(17.8±5.4)d,保留率为85.39%。不良反应发生率为15.8%,皮疹发生率为2.2%。结论拉莫三嗪是一种安全、有效的抗癫癎药物。
Objective To evaluate the clinical efficacy and safety of lamotrigine in the treatment of partial seizures in adults. Methods A total of 89 (76) patients with partial epilepsy were enrolled. Patients were given lamotrigine monotherapy, replacement or addition therapy, and open-label self-control study. The patients were followed up for 24 weeks and registered for adverse reactions. Results Among the 89 patients, 76 patients completed the end point test. The total effective rate was 82.8%. The mean effective dose was (99.7 ± 18.6) mg / d. The mean effective time was (17.8 ± 5.4) days. The retention rate was 85.39%. The incidence of adverse reactions was 15.8%, the incidence of rash was 2.2%. Conclusion Lamotrigine is a safe and effective anti-epileptic drug.