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肿瘤微环境与肿瘤细胞相互作用可以导致肿瘤细胞发生耐药,称为肿瘤微环境介导的细胞耐药(EM-DR)。EM-DR主要包括细胞黏附介导的耐药(CAM-DR)、可溶性因子介导的耐药(SM-DR)和其它途径诱导的耐药。SM-DR涉及大量的因子,这些因子主要通过促进恶性血细胞存活与增殖,抑制恶性血细胞凋亡导致细胞对药物不敏感。CAM-DR的研究主要通过肿瘤耐药细胞模型完成的,常见模型包括:球形模型、FN模型、间质模型。通过对模型研究发现肿瘤微环境可通过不同信号通路向细胞提供存活信号,从而导致耐药发生。另外肿瘤微环境还可调节耐药基因表达或局部的pH值诱导恶性血细胞发生耐药。本文就肿瘤微环境介导的恶性血液病细胞耐药的研究进展做一综述。
Interaction of tumor microenvironment and tumor cells can lead to tumor cell resistance, called tumor microenvironment-mediated cell resistance (EM-DR). EM-DR mainly includes cell adhesion-mediated resistance (CAM-DR), soluble factor-mediated resistance (SM-DR) and other pathways induced resistance. SM-DR involves a large number of factors, these factors mainly through the promotion of malignant blood cell survival and proliferation, inhibition of apoptosis caused by malignant blood cells are not drug-sensitive cells. The research of CAM-DR is mainly accomplished by tumor-resistant cell model. Common models include spherical model, FN model and interstitial model. Through the model study found that the tumor microenvironment through different signaling pathways to provide survival signals to cells, leading to drug resistance. In addition the tumor microenvironment can also regulate the expression of drug resistance genes or local pH induced malignant blood cell resistance. This review summarizes the progress in the study of drug resistance of malignant hematological malignancies mediated by tumor microenvironment.