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血液系肿瘤易感因素较多,其中包括:(1)机体防御机能减低(骨髓机能不全、淋巴-网状内皮系统机能不全);(2)抗肿瘤治疗引起继发性防御机能减低;(3)多种医源性因素诱发感染,如抗肿瘤化疗引起消化道粘膜损伤;静脉内长期留置导管及频繁输血等;(4)滥用抗生素招致体内正常菌群的失调。 1.血液系肿瘤的发热应分为感染引起的发热(FI)和肿瘤本身引起的发热(FND),常随疾病的种类而异,何杰金氏病多为FND,慢淋白血病
Hematologic malignancies are susceptible to many factors, including: (1) reduced defensive function (myelodysplasia, lymphatic-reticuloendothelial system insufficiency); (2) decreased antiproliferative response due to secondary defensive function; (3) ) A variety of iatrogenic factors induce infection, such as anti-tumor chemotherapy caused gastrointestinal mucosal injury; intravenous long-term indwelling catheter and frequent transfusions; (4) abuse of antibiotics lead to the normal body flora disorders. 1. Hematological malignancies should be divided into fever caused by infection (FI) and the tumor itself caused by fever (FND), often with the types of diseases vary, Hodgkin’s disease mostly FND, chronic leukemia