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目的:观察传染性非典型肺炎患者血清白介素 1β(IL 1β)含量变化。方法:用放射免疫法检测了6 6例SARS患者血清IL 1β含量,与正常对照组作比较。结果:进展期SARS患者血清IL 1β含量为0 2 9±0 2 0ng/ml,明显高于对照组;重型SARS患者血清IL 1β含量为0 76±0 37ng/ml,显著高于普通型SARS患者;重型SARS患者恢复期血清IL 1β含量变化多样。结论:SARS患者存在免疫反应异常,血清IL 1β含量变化可能是SARS发病机制中的一个重要环节
Objective: To observe the changes of serum interleukin 1β (IL 1β) in patients with SARS. Methods: The levels of IL-1β in serum of 66 patients with SARS were detected by radioimmunoassay, and compared with the normal control group. Results: The serum level of IL-1β in patients with advanced SARS was 0 2 9 ± 0 2 0 ng / ml, which was significantly higher than that in the control group. The serum level of IL 1β in patients with severe SARS was 0 76 ± 0 37 ng / ml, which was significantly higher than that in patients with common-type SARS The levels of serum IL-1β in convalescent patients with SARS varied greatly. Conclusion: There is an abnormal immune response in SARS patients, and the change of serum IL-1β level may be an important link in the pathogenesis of SARS